2016
Developed a method for measuring ether phospholipids in humanserum
by HPLC-ELSD method
Ref:Lipids,51(8),997-1006,2016
2015
Started open trials for people with moderate or sevior Alzheimer’s disease and other dementia symptoms on January
Ref: PLos ONE.2016,11:e0150846
2014
Started large scale clinical trials for people with mild dementia(called as
Alzheimer’s disease) for scallop derived Plasmalogen on November
Succeeded in extracting high-purity plasmalogen derived from sallops.
Safety test completed.
2013
Prove that Plasmalogen suppresses apoptosis through activation of Akt and ERK 1/2
Ref: Los ONE 2013,8:e83508
Started research on double shellfish to find for the better materials
2012
Prove that erythrocyte Plasmalogen is reduced in patients with Alzheimer’s disease
Ref: Dement Geriatr Cogn Disord Extra 2:298-303,2012 Patent pending 2010-001337
Started research on double shellfish to find for the better materials
Ref: Journal of Neuro inflammation 9:197-209,2012
Prove that oral administration of Plasmalogen increases erythrocyte plasmalogen
Ref: Lipids in Health and Disease 11:161-167,2012
Plasmalogen safety test completed
2009
Confirmation of safety and improvement effects of Alzheimer’s disease in human trial at medical institutions
2007
Successful sophystification of the Plasmalogen detection, Simplification method
Ref:Analytical Biochemistry 370:54-59,2007
2006
Discovered high purity plasmalogen extraction method from chicken meat
Patent published 2006-23296 Patent pending 2007-16056
Hall of Fame for Pioneers
Takehiko Fujino,MD,PhD.
Takehiko Fujino,MD,PhD, is an Emeritus Professor of Kyushu University. He graduated from Medical School of Kyushu University, Japan, in 1964. He is strongly interested in the integrated medicine, especially in the correlation between brain and other organs although his specialty was initially cardiology of internal medicine. He advocated a new concept “Brain Fatigue”, from which many kinds of diseases might be induced, and developed “BOOCS: Brain-Oriented Oneself-Care System”, a new method for removal of “Brain Fatigue” in 1991. It has been known that many kinds of disorders such as metabolic syndrome, depression and dementia were improved and then the death rate of those patients decreased by “BOOCS” method. As one of those researches, he has studied the correlation among “Brain Fatigue”, Alzheimer’s disease and plasmalogen.
Shiro Mawatari,MD.PhD.
Shiro Mawatari, MD, PhD, is a Director of Institute of Rheological functions of Food. He graduated from Medical School of Kyushu University (Fukuoka, Japan) in 1964, and was engaged in biochemical research on erythrocyte membrane of dystrophy at School of Medicine at the University of Pennsylvania (Philadelphia, USA) and Columbia Neuroscience, Columbia University (New York, USA) for three years and a half. After returning to Japan, he worked as an associate professor at Kyushu Institute of Technology (Fukuoka, Japan) and a professor at Fukuoka Women’s University (Fukuoka, Japan). In recent 15 years, he has been dedicated to developing technology for measurement and extraction, and to developing functional food from raw materials with its technology.
